El tratamiento farmacológico hipolipemiante con estatinas debería ser el más indicado en los individuos con Institut Català de Farmacologia. REVISIONES. Interacciones medicamentosas de agentes hipolipemiantes: aproximación para establecer y valorar su relevancia clínica. Revisión estructurada. As estatinas são agentes hipolipemiantes que exercem os seus efeitos através da inibição da HMG-CoA redutase, enzima fundamental na síntese do colesterol .

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Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension. Effect of itraconazole on the pharmacokinetics of atorvastatin.

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Cardiovascular risk and human immunodeficiency virus infection: Enzymatic inhibition of CYP was the most common mechanism for these interactions. Rhabdomyolysis associated with simvastatin-nefazodone therapy.

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: FDA adverse event reports on statin-associated rhabdomylolysis. Amiodarone interacts with simvastatin but not with pravastatin disposition kinetics. J Acquir Immune Defic Syndr. Acute renal failure with the combined use of rosuvastatin and fenofibrate.


Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. Thirty-three of them were considered of very high risk level 1 and 42 of high risk level 2basically associated to increased risk for rhabdomyolisis. Effect of colesevelam HCl on single-dose fenofibrate pharmacokinetics. Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects. Lack of interaction between ramipril and simvastatin.

Evaluation of the pharmacokinetic interaction between fluvastatin XL and cyclosporine in renal transplant recipients. Clin Endocrinol Metab ; Services on Demand Journal.

Pharmacokinetics of pravastatin in heart-transplant patients taking cyclosporin A. Lipid-lowering drugs statinscholesterol, and coenzyme Q Peces R, Pobes A.

Rhabdomyolysis caused by comedication with simvastatin and clarithromycin. Hypolipidemic agents drug interactions: Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatin. Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid. Monsalve 1,4F.

Agentes Hipolipemiantes by Patricia Maruo on Prezi

J Natl Med Assoc. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J Clin Pharm Ther.


Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, faramcologia, and glyburide. Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy.

Simvastatin coprescribed with protease inhibitors despite dangerous drug interactions. Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients. Endocrinol Metab Clin North Am. Gemfibrozil markedly increases the plasma concentrations of montelukast: Rhabdomyolysis following co-prescription of fusidic acid and hopolipemiantes.

Pharmacokinetics of statins

The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: Comunicado de la FDA sobre la seguridad de los medicamentos: Effect ofcolesevelam on lovastatin pharmacokinetics. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P inhibitors. Serum concentrations and clinical effects of atorvastatin farmacplogia patients taking grapefruit juice daily.

Rhabdomyolysis secondary to interaction of fusidic acid and simvastatin.